Startup Life/Analysis/ Starlab: the ‘Noah’s Ark’ of scientific research that launched 1,000 startup ideas Lab-concocted vodka, time travel and epilepsy treatments: welcome to the moonshot factory By Tim Smith 8 August 2022 Starlab Barcelona Starlab Barcelona \Startup Life How to keep the cofounder spark alive By Jing Ouyang 22 February 2023 Startup Life/Analysis/ Starlab: the ‘Noah’s Ark’ of scientific research that launched 1,000 startup ideas Lab-concocted vodka, time travel and epilepsy treatments: welcome to the moonshot factory By Tim Smith 8 August 2022 What happens when you round up 100 maverick scientists, working on some of the world’s most groundbreaking ideas, put them together in a Belgian castle and let them run wild? Fire extinguisher duels, bootleg vodka made with lab-procured ethanol and worldbeating treatments for epilepsy are just some of what went down at Starlab: an ill-fated experiment created by some of the world’s most daring technologists. When it was founded in 1996, Starlab was compared to other top research institutes — like Xerox’s Palo Alto Research Center — that successfully bridged the gap between idea and market. It was also a prototype for the ambitious organisations of today like Google’s “moonshot factory”, X, trying to bring entirely new ideas to the world. The original Starlab in Brussels But the centre’s idealism was to be its downfall; its pie-in-the-sky approach couldn’t pay the bills, and it went dramatically bankrupt during the dotcom crash. But what most people don’t know is that Starlab’s legacy lives on in the picturesque hills overlooking Barcelona. Many European VCs and universities claim they’re backing innovations that will solve humanity’s problems, but huge successes have been elusive. One of the companies from Starlab’s second generation has found significant success, but the centre’s tale forces anyone interested in innovation to ask themselves: how do we really bring the wildest ideas to life — and make them financially viable? The Noah’s Ark of science Starlab was established by serial entrepreneur Walter De Brouwer, MIT Media Lab founder Nicholas Negroponte and European VC pioneer Johan Konings. The idea was to create a utopian “Noah’s Ark” of science, where the brightest minds from different fields would be brought together to work on “deep future” research. Christopher Altman “De Brouwer’s idea was to bring the best scientists in the world together to ‘think thoughts for the very first time’. It was very interdisciplinary — no walls, no boundaries, no borders,” says Christopher Altman — astronaut, quantum physicist and Starlab alum. During its heyday, Starlab was home to more than 130 scientists from 36 countries, who worked on ideas ranging from time travel and consciousness to new media and “intelligent” clothing. The majority lived on site: a neoclassical castle designed in the late 1800s on the outskirts of Brussels. “It was like a pirate ship in a way, which is what I think I fell in love with. Or you could call it a kind of sect,” laughs Giulio Rufini, neuroscientist and current CEO at Starlab. “We’d stay up all night talking about time travel. Roman [Zapatrin] made his own homemade vodka using ethanol he’d pilfered from the biophysics lab down in the basement,” says Altman, referring to one of his colleagues who was a quantum topology researcher. A Starlab “Time Traveller Party” in May 2001, with (from left) Hugo de Garis, Serguei Krasnikov, Roman Zapatrin, Christopher Altman “One time in the backyard these guys covered themselves in yards of aluminium foil ‘armour’ and started duelling with fire extinguishers.” Running aground in the dotcom VC drought But how did Starlab plan to commercialise any of these wild ideas? Starlab’s research was loosely divided across four main areas: bits, atoms, neurons and genes. The BANG acronym was later adopted by MIT Media Lab (“They kind of stole that from Starlab,” says Altman). And alongside the team of swashbuckling scientists working across these disciplines, Starlab also employed a commercial team who were tasked with trying to monetise the research. Starlab’s Brussels HQ One of them was Ana Maiques, who’d recently married Rufini before they decided to both join the project. “At the time they were developing “i wear”, so like intelligent clothing with sensors. We’d reach out to Levi’s and all these companies and say, ‘Put €100k on the table per year, and then you have access to the IP that is being generated,’” she explains. “In some cases it was successful, but it was hard to replicate in others.” And while the lab was always run as a private entity, intended to be distinct from academia, commercial deals like these weren’t enough to sustain it. Maiques remembers how Starlab reflected the heady optimism that was common in the early days of the internet age, as VC capital was pumped into the institute with no urgency on getting a return on investment. “They would say ‘100 years means nothing at Starlab’. Well, for 100 years to mean nothing you need to be full of capital to develop those technologies,” she says. “The problem was that the [dotcom] bubble crash happened and they couldn’t secure the next round. It happened overnight: one day we were eating lobster and the next they came to close the company.” Altman says that when one key Swiss investor pulled their backing out of Starlab, the team began approaching people like Bill Gates to save it, but without success. “It was kind of a bummer, having set up all this stuff,” Rufini says wryly. Rebirth in Barcelona But Maiques, the more entrepreneurially minded of the recently married couple, wasn’t about to give up on Starlab. “Ana’s always had more of a business head than me, and she said, ‘Let’s just buy this and run it ourselves,’” says Rufini. Rufini and Maiques had already been working on setting up a Spanish chapter of Starlab, and had recruited 15 scientists to begin work at the Fabra Observatory, perched in the hills overlooking Barcelona. The team had already secured research contracts with the European Space Agency but, in absence of funding from the central operation, had to dramatically scale back ambitions. Ana Maquies looks up at the Fabra Observatory telescope in Barcelona “We had to take radical action, we had to lose about half of the people unfortunately,” says Rufini. “It was the crossing of the desert and it was dealing with a different type of Starlab reality.” This new reality also meant radically narrowing the scope of research. 130 scientists working across BANG were reduced to six scientists working on two core areas: space and neuroscience. It was here that Starlab began building the foundations of what would become Neuroelectrics, a non-invasive neural interface startup that raised $17.5m in 2021 to fund a Phase III trial for epilepsy treatment. The company’s Starstim headcap reads electrical brainwave data from the wearer, and can electrically stimulate areas of the brain to target treatments for conditions like Alzheimer’s and epilepsy. The Starstim headcap Apart from relying on grant funding, Maiques describes how she would go door-to-door at research companies, selling early iterations of the Starstim headcap, as well as data processing services. “We needed to pay payroll. That’s why I was going out and knocking on doors and trying to sell to companies out there, which is something that the research field never does — that kind of commercial action,” she says. ‘You’ve got to let the broth boil’ Neuroelectrics was able to self-sustain for 10 years with this bootstrapping strategy, and the company now helps finance Starlab’s research. But some of the spinout attempts haven’t been such a hit. Another commercial product Starlab launched is a satellite observation company called Greendex, which analyses the amount of vegetation surrounding real estate to assess air quality in different neighbourhoods. Ana Maiques and Giulio Rufini at Starlab’s Barcelona HQ “It hasn’t been as successful as Neuroelectrics. The market doesn’t seem ready,” says Maiques. “Spinouts are not easy. You need to have the technology, but the timing also has to align with the market.” Maiques says that, today, the space and satellite observation side of Starlab’s research has taken a back seat, with more energy going into neuroscience. Rufini and his team are now working on a project called “neuro twins” — which aims to use various data sources like MRI and EEG scans to build a digital model of people’s brains to identify how and why things might be going wrong across different pathologies. “Neuro twins is still 10 to 20 years away, so we still have the long-term science vision with the short-term focus on return on investment. We never abandoned shooting for the moon in deeptech areas and we’re still finding grants to sustain that,” says Maiques. “It’s like a broth. You have to give it time to boil.” A Starlab researcher works on circuitry for a Starstim headcap Making science useful While Neuroelectrics is the commercial poster child for the current iteration of Starlab, the institute’s 25-year history has contributed to countless areas of innovation. The “i wear” smart clothing project was eventually sold to Phillips, while another biotech company, Bioprocessors, was spun out and relocated to Silicon Valley. Rufini adds that a whole host of ideas that are now commonplace were born at Starlab. “I came up with the idea that, pretty soon, cars will have the internet and we could use that information to forecast traffic,” he says. “There was another one called ‘spitters.com’, where you could send off spit samples to your genotype. There was another one called ‘pajamanation.com’, which was a marketplace for jobs for people working from home.” Giulio Rufini plays piano in his office Some argue that Starlab’s greatest legacy isn’t in the scientific advances or spinoff businesses that it created, but in the way it encouraged those who walked through its doors to think in a truly unique way. Altman went on to work at quantum research projects for NASA and the US government, and later launched renewable energy cryptocurrency SolarCoin with fellow Starlab alum Nick Gogerty. Today he’s still not afraid to attach his name to speculative science, and is a cofounder of UAPx, a non-profit scientific research organisation studying the UFO phenomenon. “There are paradigm shifting technologies to be discovered if we can get to the bottom of it [the phenomenon],” he says. “Confirmation of extraterrestrial artefacts would quite readily qualify as the single greatest discovery made by the human race.” Maiques adds that no less than eight former researchers at Starlab Barcelona have gone on to start their own companies, in fields ranging from virtual reality to earth observation radar. This entrepreneurial spirit, she believes, is something that’s baked into Starlab’s business model, and something that she says is sorely lacking in European academia. A Starlab mascot sports a Starstim skullcap “In Europe we are good at turning money into knowledge, but we’re really bad at turning knowledge back into money,” she says. “I honestly cannot think of a private company doing science in such a way with this model to create spinoffs. We always had the drive to go to the market and make money. It’s just a different vibe.” Starlab’s director of neuroscience, Aureli Soria-Frisch, agrees that European science all too often gets stuck in the lab. “There is a lot of very interesting science in Europe. But how can we make this useful for people? We need better licensing policies and career development support outside of academia,” he says. In that sense, Starlab’s story serves as a microcosm for this big question in European tech: how can we make the most of the continent’s scientific innovation? The project’s first chapter serves as a warning for what can happen when venture capital flows into ideas without a viable business model. Its second chapter is a lesson in how great research can be done with the market in mind, given the right conditions. Europe, so far, just hasn’t excelled in creating those conditions. Tim Smith is Sifted’s Iberia correspondent. He tweets from @timmpsmith Related Articles Forget the negative headlines about tech jobs, UK tech is very much still hiring By George Windsor Click here to read more Four tips for managing compliance risk while scaling across borders By Aruni Sunil Click here to read more Expect surprises says Silva as Santander InnoVentures goes on shopping spree By Maija Palmer Click here to read more Chunky cheques and bold bets: Five ways to prepare for your Series A By Dalvinder Kular Click here to read more Most Read 1 \Healthtech Is Daniel Ek’s new body scanner worth the hype? 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